Stress affects every persons‚ health and well being, significantly and vastly. Occupation stress negative effects are bolder in workplaces; both as a disease agent and as an obstacle to employee's productivity and satisfaction. Although occupational stress has various sources, and designers have no control over many of them, there is a group of interventions that are design related. In this research, those design strategies to mitigate stress are considered as environmental interventions. The literature on occupant health, well-being, satisfaction, and productivity are huge and multi-directional; however, this research is limited to stress factors that correlated with the built environment and focus on employees who are experiencing a high rate of stress in office buildings as the target group. Due to that, the researcher finds evidence of environmental interventions that can reduce stress or enhance the stress-coping abilities of workers in offices by design and environmental health improvement. The questions that this research is answering are; what are the main environmental factors in offices that can help the employees experience lower stress or help them to mitigate the stress after facing it? How can space cause people to stress? How do stress and built environment collaborate? This research is based on the cross-disciplinarily systematic literature review of architecture, planning, public health, medical, management, and psychological sciences. The outcome of this research is the set of strategies to provide solutions for healthier and productive working places in offices with a concentration on the reduction of the stress level of employees, which can be used as a source for workplace evidence-based designs. These strategies are discussed in three realms: urban, architecture, and conjunction area as a mediator between outside and inside.