Hantavirus is a zoonotic RNA virus that causes Hemorrhagic Fever with Renal Syndrome (HFRS) and Hantavirus Pulmonary Syndrome (HPS) in humans. Since the first reported case in the US in 1975, there have been approximately 118 HPS cases in New Mexico (NM). Since the majority of the cases are from northwestern NM, minimal attention has been given to the eastern portion of the state. However, the literature suggests there is a potential overlap of the Sin Nombre (SNV), El Moro Canyon, and Muleshoe virus in the eastern NM, and a recent study found six species tested positive for hantavirus antibodies. Here, we aim to investigate hantavirus antibody seroprevalence, identify hosts, and genetically confirm the viral strains across eight under surveyed counties in eastern NM. To date, we have surveyed 13 sites over 19,500 trap nights and captured 400 individuals belonging to two families: 32% Heteromyidae and 68% Cricetidae. Seven species we have captured are known hantavirus hosts. Species richness ranged from two to eight species per site, while capture per unit effort varied from 1% to 5%. Thus far we were able to test a subset of lung tissue samples of Peromyscus sp. and confirm the presence of SNV and non-SNV hantaviruses. In spring 2021, we will begin enzyme-linked immunosorbent assays (ELISA) to test blood samples for the presence of hantavirus specific antibodies and continue to genetically test individual positive lung samples for hantavirus strains. This study significantly expands our understanding of hantavirus species distribution, hantavirus prevalence among their respective hosts, and has a potential to illuminate any spillover events and/or discovery of novel hantaviruses.